Effective Treatments for Invasive Lobular Carcinoma


Intro
Invasive lobular carcinoma (ILC) is a unique and often elusive form of breast cancer. While many may view all types of breast cancer as similar, ILC sets itself apart through distinct biological characteristics and behaviors. Recognizing its subtleties isn't just an academic exercise; it shapes the foundation for effective treatment strategies that can greatly influence patient outcomes.
This article endeavors to outline the available therapies for ILC, comprehensively examining the latest surgical options, systemic treatments, and the emerging frontiers of personalized medicine. Through this narrative, we’ll delve into how these strategies can address the challenges posed by ILC, bringing light to what makes managing this condition distinctively complex.
Research Overview
Summary of Key Findings
Invasive lobular carcinoma typically presents later than other breast cancer types, often leading to a delay in diagnosis and treatment. Research indicates the need for tailored treatment plans that can address the specific growth patterns of ILC. Key findings from recent studies emphasize:
- Surgical intervention remains a cornerstone strategy but has evolved, with considerations around breast-conserving options gaining traction.
- Systemic therapies, including hormone therapy and chemotherapy, show varying degrees of efficacy, particularly in patients with hormone receptor-positive tumors.
- Emerging research highlights the role of personalized medicine, where genetic profiling may serve as a guide for therapy choices.
Research Objectives and Hypotheses
The objective of this exploration is to collate recent advancements in the treatment of invasive lobular carcinoma and establish a clear understanding of effective methodologies. The hypotheses driving our research activities include:
- Treatment efficacy is significantly enhanced when approaches align with the biological characteristics exhibited by ILC.
- There could be a notable discrepancy in treatment response between ILC and other breast cancer types due to its distinct cellular architecture.
This aligns with the overarching aim of not just improving therapy outcomes but also ensuring that the management of ILC is as personalized as possible, adapting to the nuances of each patient’s condition.
Methodology
Study Design and Approach
The methodologies employed in this article rely on an extensive review of existing clinical literature, guidelines, and recent research articles. A qualitative approach focuses on analyzing outcomes from case studies and clinical trials.
Data Collection Techniques
Data was gathered from reputable medical journals, online databases like PubMed, and recommendations from cancer research organizations. This multi-faceted approach ensures that our exploration reflects a well-rounded perspective on current treatment modalities.
"The journey through understanding invasive lobular carcinoma is akin to navigating a labyrinth; it requires both knowledge and intuition to find the best path forward."
In this article, we’ll focus on dissecting the current treatment landscape for ILC, shedding light on its complexities while recognizing the pressing need for research and development in more effective therapeutic strategies.
Understanding Invasive Lobular Carcinoma
Grasping the fundamental aspects of Invasive Lobular Carcinoma (ILC) is essential not just for healthcare professionals, but also for patients and their families. This understanding sets the stage for navigating the treatment landscape more effectively. The importance of recognizing ILC lies mainly in its unique biological behavior, which often diverges from other breast cancer subtypes.
The subtlety with which ILC tends to grow and spread can lead to an underestimation of its severity during diagnosis. Therefore, comprehending its distinctive characteristics allows for timely intervention and better management strategies. The complexity of ILC treatment isn't merely academic; it can have tangible implications for patient outcomes. By delving into the particulars, we can illuminate pathways that may otherwise remain shrouded in ambiguity.
Defining Invasive Lobular Carcinoma
Invasive Lobular Carcinoma is a particular form of breast cancer that stems from the lobules, the milk-producing glands of the breast. Unlike the more common invasive ductal carcinoma, ILC often presents itself in a less defined pattern. The cells in ILC tend to invade surrounding tissues in a more diffuse manner, which can often make it harder to detect through standard imaging techniques such as mammograms.
Moreover, its histological appearance shows small, non-cohesive cells that resemble a "single-file" pattern. This unique structure is what distinguishes ILC from other breast tumors and requires specialized approaches for both diagnosis and treatment.
Distinct Characteristics of
The characteristics of Invasive Lobular Carcinoma are crucial to recognize for effective therapeutic strategies. The following points highlight the primary attributes:
- Hormonal Sensitivity: ILC is frequently estrogen receptor-positive, making it often responsive to hormonal therapies, such as tamoxifen or aromatase inhibitors.
- Less Likely to Form a Lump: Unlike other types of breast cancer, patients with ILC might not notice a distinct mass. Symptoms can include subtle breast changes.
- Higher Risk of Bilateral Occurrence: Women diagnosed with ILC face a greater risk of developing cancer in the opposite breast compared to those with invasive ductal carcinoma.
Knowing these characteristics helps in tailoring individual treatment plans and improves understanding of the disease's behavior.
Epidemiology and Risk Factors
When it comes to ILC, epidemiological studies reveal insights about incidence and risk factors unique to this subtype. Statistics indicate that around 10-15% of breast cancer cases are classified as invasive lobular carcinoma. Several risk factors influence the probability of developing this cancer, including:
- Age: ILC generally manifests in older women, often during or after menopause.
- Family History: A significant family history of breast cancer can elevate an individual’s risk.
- Genetic Factors: Variants of the BRCA1 and BRCA2 genes are correlated with breast cancer, including ILC.
- Estrogen Exposure: Prolonged exposure to estrogen due to factors like early menstruation or late menopause contributes to risk.


Diagnosis of Invasive Lobular Carcinoma
Diagnosing invasive lobular carcinoma (ILC) is a critical step in the journey of patients facing this unique subtype of breast cancer. Accurate diagnosis not only guides treatment choices but also affects prognosis and patient outcomes. Given the nuanced character of ILC, which often behaves differently from its more common counterpart—invasive ductal carcinoma—understanding various diagnostic methods becomes imperative for healthcare professionals and patients alike.
Screening and Detection Methods
Screening for ILC typically begins with routine mammograms. However, the unique growth pattern of lobular carcinoma often leads to challenges during detection. Unlike the more mass-forming types of breast cancer, ILC presents with less defined boundaries, which may result in missed diagnoses during standard imaging.
Some notable screening methods include:
- Clinical Breast Exams: These are essential, even in the absence of palpable lumps. Careful monitoring can sometimes reveal subtle changes.
- Digital Mammography: Advances in imaging technology, such as digital mammograms, allow for enhanced visualization and can aid in better detection rates of ILC.
- Breast Ultrasound: This method can be particularly useful for women with dense breast tissue, where traditional mammograms might not be as effective.
- Magnetic Resonance Imaging (MRI): While not a first-line screening tool, MRI provides a clearer view of breast tissue architecture and can be employed when suspicion remains high despite inconclusive mammograms.
All in all, an individualized approach to screening, tailored to each patient’s risk factors, is crucial for the effective detection of ILC.
Histopathological Assessment
Upon suspicion of ILC, biopsy plays a paramount role in confirming the diagnosis. An accurate histopathological evaluation helps determine not only the presence of malignancy but also the tumor's specific characteristics.
- Core Needle Biopsy: This is a common and minimally invasive procedure that allows for adequate tissue sampling. Results from the biopsy guide the oncologist in staging and treatment decisions.
- Fine-Needle Aspiration: Less commonly used, this method may still be employed for aspirating fluid from lesions, although it might not yield sufficient tissue for comprehensive analysis.
- Histological Examination: Once the tissue is obtained, pathologists examine it under a microscope, looking for cellular features characteristic of ILC, such as small tubular structures and lack of desmoplastic response.
Understanding the histopathological nuances is crucial for determining the best course of therapy and understanding the biological behavior of the cancer.
Imaging Techniques
Imaging techniques play a vital role in staging ILC and determining its extent before treatment begins. Beyond mammography, various imaging modalities provide critical insights:
- Ultrasound: Helpful in assessing the local extent of the lesion and evaluating lymph nodes in the axillary region, ultrasound is often used alongside other imaging methods.
- MRI: MRI not only assists in diagnosis but also provides a more comprehensive picture of multifocality or bilateral disease, which is not uncommon in ILC cases.
- CT and PET Scans: While not used routinely for initial diagnosis, these imaging modalities are instrumental in assessing metastatic disease, especially when symptoms suggest distant involvement.
Current Treatments for Invasive Lobular Carcinoma
Understanding the various therapies available for Invasive Lobular Carcinoma (ILC) is paramount in addressing the unique challenges posed by this cancer subtype. The treatment landscape is multi-faceted, encompassing a blend of surgical interventions and systemic therapies. Each treatment carries its own set of benefits and pitfalls that necessitate thorough evaluation by healthcare professionals. Tailoring each case is essential, as no two patients present the same way; the importance of current treatments lies in their ability to optimize outcomes, mitigate symptoms, and ultimately improve the quality of life for those affected.
Surgical Interventions
Surgical interventions play a pivotal role in the management of ILC. They are often the first line of defense and may lead the charge in successful treatment outcomes. Ultimately, the goal of these procedures is to maximize tumor removal while preserving as much healthy tissue as possible. Let's delve into specific types of surgical options available.
Partial Mastectomy
Partial mastectomy, or lumpectomy, is a procedure that involves the removal of the tumor along with a margin of surrounding healthy tissue. This approach is often preferred for ILC due to its breast-conserving nature. One of its key benefits is that it allows for the preservation of the breast's appearance and structure, which can be a significant psychological advantage for many women.
However, a unique aspect of this surgery is the potential need for follow-up radiation therapy to address any remaining cancer cells. While the risks associated with partial mastectomy are generally lower compared to more radical options, it may not be suitable for all patients, particularly those with larger tumors or multifocal disease.
Total Mastectomy
Total mastectomy involves the complete removal of the breast and is often considered when there are concerns about the extent of disease or when partial mastectomy may not achieve clear surgical margins. This approach is particularly favorable for patients with widespread invasive lobular carcinoma or when prior lumpectomy has failed.
The major benefit of total mastectomy is the reduced risk of recurrence at the surgical site. Moreover, it simplifies post-operative monitoring and follow-up care, as there are no remaining breast tissue cells to consider. On the flip side, many patients grapple with the emotional and physical toll of losing a breast, which can affect their self-image and quality of life.
Surgical Margins and Implications
The concept of surgical margins cannot be overlooked in the discussion of surgical interventions. Clear margins—indicating that no cancer cells were found at the edge of the removed tissue—are crucial in determining the success of the surgery. The implications of surgical margins are significant; the presence of cancer cells at the margins can lead to additional treatments, such as further surgery or radiation.
Moreover, clear margins increase the likelihood of improved long-term outcomes. Yet, achieving clear margins can sometimes be tricky, especially with ILC, where the cancer can be more insidious and may not present as well-defined masses compared to other breast cancer subtypes. Therefore, the surgical team must be vigilant and thorough during procedures.
Systemic Therapy Options
After surgical interventions, systemic therapies are frequently employed to address any residual disease or to target distant metastases. These can include chemotherapy, hormonal therapy, and targeted therapy.
Chemotherapy
Chemotherapy, though often daunting to many patients, is a cornerstone treatment option for ILC, particularly in advanced cases. It employs a cocktail of drugs that work to kill cancer cells or hinder their growth. Its primary characteristic is versatility in addressing various stages of cancer, and it acts on cells throughout the body, making it effective especially when there's a risk of metastasis.
However, the downside of chemotherapy lies in its systemic side effects; patients can experience fatigue, hair loss, nausea, and other discomforts during treatment. Determining the appropriateness of chemotherapy involves weighing these side effects against potential survival benefits, a task that requires nuanced discussions between patients and oncologists.


Hormonal Therapy
Given that invasive lobular carcinoma often expresses hormone receptors, hormonal therapy can be tailored to work effectively against this subtype. This therapy aims to block the body's natural hormones that fuel some cancer growth, particularly targeting estrogen, which can be a driver in hormone receptor-positive ILC cases.
This treatment is generally well-tolerated, presenting a distinctly less taxing alternative compared to chemotherapy. Yet, it may not be suitable for all patients—those without hormone receptors won't benefit, and some may experience side effects like hot flashes and mood changes.
Targeted Therapy
Targeted therapy utilizes drugs that attack specific characteristics of cancer cells, providing a more focused approach compared to traditional chemotherapy. In the context of ILC, this could include agents targeting specific mutations or protein expressions common in lobular cancers. The uniqueness of targeted therapy brings about tailored treatment regimens, which can lead to superior outcomes for select patients.
However, this approach also necessitates prior genetic or biomarker testing to identify the suitable candidates. Such treatments may come with their own side effects, sometimes less predictable than those of conventional therapies. As the field evolves, ongoing research continues to unveil new targeted therapy options, creating hope for better precision in ILC management.
Emerging Therapies for Invasive Lobular Carcinoma
Emerging therapies in the realm of invasive lobular carcinoma (ILC) are gaining traction. As understanding of this unique breast cancer subtype heightens, new avenues for treatment are becoming available. These therapies not only aim to improve survival rates but also focus on tailor-fitting treatment to individual patient needs. The progression of these options is not merely a glimmer of hope; it’s a vital piece in the puzzle of ILC management.
Investigation of Novel Agents
Recent research has spotlighted various novel agents that target pathways unique to invasive lobular carcinoma. Unlike traditional therapies, these agents are designed considering the peculiar biology of ILC. For instance, PARP inhibitors, like olaparib, have shown promise in preclinical studies. They take aim at tumors with BRCA mutations, which are not just concerns in hereditary breast cancers but may also be applicable in sporadic cases of ILC.
Additionally, immune checkpoint inhibitors have been evaluated. These agents, such as pembrolizumab, enhance the body's immune response against tumor cells. They’ve been successful in other cancers, and ongoing trials are determining their efficacy in ILC. It’s a waiting game, but researchers are dabbling with combinations of therapies to maximize treatment impact.
"Emerging therapies like novel agents might usher a new era in invasive lobular carcinoma treatment, enhancing potential outcomes for patients."
Understanding how these agents work at a molecular level is a continuous process. With an eye towards precision medicine, treatments can be honed to target the exact mechanisms at play in each patient's tumor.
Clinical Trials and Their Importance
Clinical trials serve as the backbone for testing emerging therapies, providing a structured approach to assess their safety and effectiveness. They are often the first stepping stone to bringing a breakthrough therapy to the forefront. At this moment, numerous trials are ongoing, focusing on the novel agents we discussed, and their results are awaited with bated breath.
Participating in a clinical trial can offer patients access to the latest treatment options, sometimes even before they are widely available. However, it’s crucial to consider the benefits and risks involved. Not every patient may be a good candidate, and medical teams often weigh these factors before enrolling someone.
In particular, trials examining combinations of existing therapies with emerging agents show promise. These combinations could potentially lead to better outcomes compared to current treatment pathways alone. Understanding the design and intent behind these trials can empower patients to make informed decisions regarding their treatment options. Thus, the importance of ongoing research cannot be overstated—it's a path toward innovation in treating invasive lobular carcinoma.
Personalized Medicine in Treatment
Personalized medicine has become a cornerstone in understanding and treating invasive lobular carcinoma (ILC). Unlike traditional methods that take a one-size-fits-all approach, personalized medicine tailors treatment to the individual characteristics of each patient and their specific cancer profile. This strategy utilizes various tools and technologies to discern the molecular makeup of a patient’s tumor, paving the way for treatments that are more effective and better tolerated.
The significance of personalized medicine in ILC treatment cannot be overstated. By focusing on specific genetic changes and tumor behavior, healthcare providers can make more informed decisions that align with the patient's unique health considerations. This leads to several benefits:
- Targeted Therapies: By identifying specific genetic mutations within the ILC, oncologists can utilize targeted therapies that directly address these alterations. For example, alterations in the CD gene may lead to specific treatments aimed at these pathways.
- Reduced Side Effects: With a more tailored approach, the incidence of adverse side effects can be minimized. When treatments are chosen based on genetic profiling, there’s a better chance that they will work effectively without causing excessive harm to healthy tissues.
- Improved Outcomes: Personalized treatment strategies are often associated with better overall patient outcomes. By ensuring that the therapies align with the biological characteristics of the tumor, the chances of a successful response increase.
Genetic Profiling and Treatment Decision
Genetic profiling plays a crucial role in the realm of personalized medicine, especially in the treatment of ILC. This process involves analyzing a patient’s tumor to identify specific genetic mutations or biomarkers. Such information directly influences treatment decisions.
In some cases, patients with ILC may have unique mutations that make standard treatments less effective. Hence, genetic profiling can reveal:
- Hereditary Mutations: Examples include mutations in the BRCA genes, which might necessitate different treatment pathways or surgical decisions.
- Tumor Aggressiveness: Certain genetic markers might indicate a more aggressive form of cancer, prompting clinicians to opt for more aggressive treatment regimens.
Understanding these nuances not only allows clinicians to devise a more suitable treatment plan but also fosters engaging conversations about options and potential outcomes with patients.
"Genetic profiling is not just a tool; it’s a pivotal part of tailoring treatment to the patient's specific cancer type, which in this case is invasive lobular carcinoma."
Biomarkers and Their Relevance
Biomarkers serve as crucial indicators in the landscape of ILC treatment. They are molecules that are associated with a specific disease state and can be found in blood, other body fluids, or tissues. In the context of invasive lobular carcinoma, relevant biomarkers can guide treatment pathways and provide insights into prognosis.
- Hormone Receptors: Hormone receptor status, such as estrogen and progesterone receptors, is a well-known biomarker that significantly impacts treatment decisions. Patients with hormone receptor-positive ILC may benefit from hormonal therapies like tamoxifen or aromatase inhibitors.
- HER2 Status: Another important biomarker is the HER2 status of the tumor. Knowing whether a tumor is HER2-positive can dictate the use of targeted therapies like trastuzumab, which can enhance treatment effectiveness.
- Genetic Mutation Indicators: Some biomarkers indicate the presence of specific mutations that may inform the use of targeted therapies, providing a pathway that traditional methods might overlook.
Patient Management and Support


Patient management and support play a vital role in the treatment of Invasive Lobular Carcinoma (ILC). It’s not just about tackling the cancer itself but also about addressing the holistic needs of the patient throughout the entire journey from diagnosis to survivorship. When someone is diagnosed with ILC, it’s not only a medical challenge; it often leads to significant emotional and psychological strain. So, how one manages this aspect can greatly influence patient outcomes.
Providing robust support not only enhances the patient’s experience but helps them cope with treatment side effects, psychological distress, and the uncertainty that often accompanies a cancer diagnosis. Many patients find themselves grappling with a host of emotions—fear, anxiety, or even sadness—due to their condition and treatment regimen. Therefore, establishing a comprehensive support system is paramount. This encompasses various elements including psychosocial support, educational resources, and efficient follow-up care, ensuring that patients are not just surviving, but also thriving in their daily lives.
Psychosocial Support for Patients
Psychosocial support is a critical component when managing invasive lobular carcinoma, as it addresses the emotional, social, and psychological needs that arise during cancer treatment. Unlike other forms of cancer, ILC may present unique emotional challenges due to its subtle symptoms and less conventional presentation.
Healthcare providers and support groups can offer various resources that help patients share their feelings and experiences in a safe environment. Being in touch with others who share similar challenges can be quite comforting. This connection can be achieved through:
- Support Groups: These allow patients to share their journey, providing a sense of community.
- Therapist or Counselor Involvement: Professionals trained in dealing with cancer-related trauma can assist patients in navigating their fears and concerns.
- Educational Workshops: Teaching patients about their condition can empower them, making them feel more in control.
According to studies, patients engaged in psychosocial support initiatives often report a reduction in anxiety and enhanced coping strategies, positively influencing their overall treatment journey.
Moreover, having family members involved in these support activities can help integrate both emotional and practical support systems, alleviating the burden on the patient.
Survivorship and Follow-Up Care
Survivorship care takes center stage after the initial treatment phase concludes. It's where the focus shifts to living well after ILC and addressing long-term effects and potential recurrence. Follow-up care should be comprehensive, including regular medical check-ups, screening for any post-treatment complications, and monitoring any signs of cancer returning – which can sometimes happen, despite successful treatment.
Key aspects to consider in this phase include:
- Regular Screening: Incorporating routine imaging and lab tests tailored to the individual patient's history helps catch any issues early on.
- Lifestyle Changes: Guidance on nutrition, exercise, and overall wellness can significantly impact long-term health post-treatment. Encouraging exercise regimens or dietary alterations can aid in fostering a healthier routine and potentially reduce recurrence risk.
- Education on Symptoms: Equipping survivors with knowledge about changes to watch for can prepare them to identify issues early and facilitate swift action.
Some follow-up care might also extend beyond physical health to further support patients' mental health needs, ensuring they have access to resources that help them adjust and thrive in their post-cancer lives.
In summary, focusing on patient management and support is crucial in navigating the journey through invasive lobular carcinoma. By ensuring patients receive solid psychosocial backing during treatment and thorough follow-up care afterward, healthcare providers can significantly enhance the quality of life and outcomes for ILC patients.
Future Directions in Research
Research into invasive lobular carcinoma (ILC) is gaining speed, reflecting a critical need to understand this unique breast cancer subtype better. The distinct biological characteristics it exhibits mean that traditional treatment modalities may not always be effective. Future directions in research will not only seek to refine existing treatments but also explore the molecular pathways driving ILC. This could ultimately spearhead the development of innovative therapies tailored specifically for this form of cancer, providing more nuanced care for patients.
Innovative Approaches to
In recent years, scientists have turned their attention toward novel therapeutic strategies that could reshape the management landscape of ILC. For instance, researchers are increasingly interested in the role of immune checkpoint inhibitors, which have demonstrated success in various cancer types.
- Immune Checkpoint Inhibitors: These agents, such as Pembrolizumab or Nivolumab, aim to enhance the body's immune response against cancer cells. Their effectiveness in ILC remains under investigation, but early trials suggest a degree of promise in achieving better treatment responses.
- Targeting Genetic Alterations: There is a push to identify specific genetic mutations prevalent in ILC. By using drugs that target these genetic anomalies, oncologists might personalize treatment further. For example, agents that inhibit the effects of specific mutations found in patients may significantly improve outcomes.
Also noteworthy is the advent of precision oncology, where treatment plans incorporate a comprehensive understanding of the patient's genetic makeup. This method can dramatically shift the treatment course, moving away from a one-size-fits-all approach.
"The future of ILC treatment lies in understanding its genetic architecture; this might just be the key to unlocking more effective therapies."
Integrating Multidisciplinary Care
Integrating a multidisciplinary approach to ILC treatment is becoming increasingly recognized as essential. This approach involves collaboration among various healthcare providers, including medical oncologists, surgical teams, radiologists, and pathologists. Such teamwork fosters a more holistic view of patient care.
- Collaboration for Optimal Outcomes: By working together, teams can develop comprehensive treatment plans that consider all facets of a patient's health, including psychological and social factors. Regular tumor board meetings, where healthcare professionals dissect each case, can lead to shared learning and improved treatment strategies.
- Personalized Care Plans: This model encourages the personalization of care. Each team member contributes expertise, enabling the formation of tailored approaches based on the latest research.
- Continuous Education and Updates: Multi-disciplinary care also emphasizes continuous education. Keeping all team members updated on the latest advancements can facilitate rapid adjustments to patient treatment plans based on emerging evidence.
As future research continues to advance, integrating these innovative approaches within multidisciplinary frameworks will likely hold great promise for improving outcomes for patients diagnosed with invasive lobular carcinoma.
Finale
The exploration of effective treatments for invasive lobular carcinoma (ILC) is not just a matter of medical curiosity; it has real-world implications for patients and their families. Understanding the landscape of current therapies, emerging options, and future directions can empower a pivotal shift in patient outcomes. This section will summarize key treatments and address the broader impacts these advancements may hold.
Summary of Effective Treatments
In the fight against ILC, several treatment modalities showcase promising benefits for patients. They include:
- Surgical Interventions: Depending on the stage and extent of cancer, surgical options such as partial mastectomy or total mastectomy are often the first line of treatment. Ensuring clear surgical margins can drastically reduce the risk of recurrence.
- Systemic Therapies: Treatments such as chemotherapy, hormonal therapy, and targeted therapy help address systemic disease. These can complement surgical approaches, especially in later stages of ILC.
- Emerging Therapies and Personalized Medicine: With ongoing research into innovative treatments and biotechnology, the field is swiftly evolving. Genetic profiling allows for tailored treatment plans, aligning therapies with individual patient profiles to potentially enhance effectiveness.
Overall, the integration of these treatments reflects a multidimensional strategy to combat ILC, addressing not only the disease itself but also improving quality of life.
Looking Ahead: Implications for Patients
As we cast our gaze toward the future, the implications for patients become even clearer. The importance of personalized medicine can’t be overstated. As each patient's cancer presents uniquely, the ability to tailor treatments based on genetic and biological factors affords a hope for better responses and fewer side effects.
- Clinical Trials: Patients are encouraged to consider participation in clinical trials. These studies not only offer access to cutting-edge therapies but also contribute significantly to the medical community’s understanding of ILC.
- Support Networks: In addition to treatment, the emotional and psychological support available can greatly influence recovery. Organizations and patient communities provide invaluable resources.
"The journey does not end with treatment; rather, it often requires ongoing survivor care and support."